1st Circ. Spots 'Gap' In Cancer-Drug Suit Against Karyopharm

By Chris Villani (February 8, 2022, 2:49 PM EST) -- A First Circuit panel appeared receptive Tuesday to claims that Karyopharm Therapeutics Inc. executives gave an overly rosy assessment of negative drug trial results, but questioned whether investors could show the statements were intentional. 

During oral arguments, the appeals court weighed a pair of statements by Karyopharm higher-ups claiming the company's cancer-fighting drug, Selinexor, had demonstrated "a predictable and manageable tolerability profile" and touting the success of a so-called STORM study as a "significant step in establishing the efficacy and safety" of the drug.

The investors say claims that Selinexor caused only mild side effects were false. In fact, according to the suit, every...

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